Abstract
Sera from 25 patients with varying degrees of acne vulgaris and sera from 23 patients without acne were tested for antibody levels to Corynebacterium acnes using the complement-fixation test. Results indicate that levels of complement-fixing antibodies to C. acnes are significantly higher in patients with acne than in control groups. Antigen prepared from disrupted C. acnes was found to be reactive in the complement-fixation test.

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