6-MERCAPTOPURINE-RESISTANT LINE OF DJUNGARIAN HAMSTER CELLS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 12  (12) , 56-+
Abstract
A cell line resistant to 6-mercaptopurine (6-MP) is isolated from Djungarian hamster embryonic fibroblasts transformed with SV-40 virus. 6-MP resistance is due to the absence or complete inhibition of HGPRT [hypoxanthine guanine phosphoribosyl transferase] activity. Initial and resistant cell cultures are similar in the growth rate and in the inoculation efficiency. Karyological analysis (differential chromosome staining.sbd.S-bands) revealed considerable karyotype rearrangements in both resistant and sensitive lines as compared with Djungarian hamster normal chromosome set, and the appearance of specific chromosome markers.

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