Two Classes of Homocytotropic Antibodies in the Rhesus Monkey

Publisher Website
Google Scholar
Abstract
Rhesus monkeys injected intravenously with TNP-KLH produced homocytotropic antibody separable into two components on ion exchange chromatography, a heat-labile γ1- and a heat-stable γ2-immunoglobulin. Homocytotropic antibody was directed against the TNP group only, though both groups of determinants gave rise to large amounts of precipitating antibody. Arthus reactions induced by TNP on heterologous carrier were more severe than those caused by KLH. Prolonged TNP-induced reactions resembled delayed hypersensitivity reactions grossly and histologically. Anaphylaxis occurred in a few of the animals in response to TNP-KLH, but not to KLH alone, although no relationship to levels of homocytotropic antibody was discernible.

This publication has 0 references indexed in Scilit: