A Blind Family History Study of Briquet's Syndrome

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Abstract
• We undertook a blind family history study of Briquet's syndrome to complement earlier follow-up work by Perley and Guze. The same criteria were used in a chart review to select 49 Briquet's syndrome cases. One control group consisted of consecutive "non-Briquet hysteria" admissions and another of matched primary unipolar depressed cases. First-degree relatives of the Briquet's syndrome probands had significantly less affective disorder and more "complicated medical history" then either control group. The "non-Briquet hysteria" group contained more family histories with instances of schizophrenia than either the Briquet's syndrome or affective disorder groups. These results provide additional validation of the Briquet's syndrome diagnosis.

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