Experiments on the Radioprotective Action of Dimethyl Sulphoxide
- 1 January 1963
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 6 (2) , 151-155
- https://doi.org/10.1080/09553006314550151
Abstract
The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice. The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes. The mechanism of action of dimethyl sulphoxide in the mouse is discussed.Keywords
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