COMBINATION PERFUSION–COLD STORAGE FOR OPTIMUM CADAVER KIDNEY FUNCTION AND UTILIZATION

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Abstract
Dog kidneys were perfused with a newly developed perfusate containing adenosine and PO4 for 48 h, stored in the same perfusate for an additional 24 h without perfusion (total preservation time: 72 h), and transplanted with immediate contralateral nephrectomy. Posttransplant renal function and biochemical analysis of the kidneys revealed practically no additional preservation-induced damage during the cold storage period. Serum creatinine levels reached normal between the 3rd-8th day posttransplant. This preservation method may be the method of choice for patients receiving postoperative cyclosporin therapy; it may also facilitate organ sharing between transplant centers, thus reducing wastage of cadaveric kidneys.