NEW POTENTIAL CYTO-TOXIC AND ANTI-TUMOR SUBSTANCES .3. INVITRO EFFECT OF 3-BENZAZEPINE DERIVATIVES ON P388 CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 27  (6) , 703-709
Abstract
3-Benzazepine derivatives manifested cytotoxic effects in in vitro tests on [mouse] lympholeukemia P388 cells. The most efficient derivative (QF 1), i.e., 7,8-dihydro-3,4,12-trimetoxy-7-dimethylamino-10,11-methylenedioxy-5H-indolo [1,2-b][3]benzazepine-5-one, in a concentration as low as 5 .mu.l/ml considerably inhibited the incorporation of labeled uridine into P388 cell fractions. In in vitro experiments, this substance blocked cell proliferation. After its prolonged action, the number of dead cells increased; this also occurred when its interaction with the cells lasted a short time, the substance being removed from the medium. The substance probably retains the cells in the G1/S phase. A marked synergistic effect of tubercidin was attained in the presence of the substance.

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