Interaction Aspects of Antimycobacterial Drugs in the Chemotherapy of Tuberculosis

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Abstract
The concentration related interaction of rifampicin, in associations with isoniazid, ethambutol, streptomycin and p-aminosalicylic acid on M. tuberculosis (H37Rv) in vitro has been statistically evaluated. The independency or dependency of drugs has been assessed either on the basis of their concentrations or their proportions in associations studied. The effect of drug-resistant mutants has been excluded. The data indicate that rifampicin and ethambutol act dependently in a wide range of concentrations and proportions, both drugs participate equally on the increased effectivity of a given association. In associations of rifampicin with other drugs the dependent (increased) interaction is limited to some concentrations, particularly of rifampicin.

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