Relations between opiate receptor binding and analgetic properties of prodine-type compounds
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 309-310
- https://doi.org/10.1021/jm00212a026
Abstract
The receptor binding affinities [using rat brain homogenates] of some diastereoisomeric prodine analogues were compared with their analgetic activities determined by the hot-plate test in mice. The close correlation found between these potencies indicates that the relative analgetic activities of the .alpha./.beta. isomers are determined primarily by the appropriate association to the receptor sites.This publication has 0 references indexed in Scilit: