Captan Metabolism in Humans Yields two Biomarkers, Tetrahydrophthalimide (THPI) and Thiazolidine-2-Thione-4-Carboxylic Acid (TTCA) in Urine
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 16 (2) , 207-225
- https://doi.org/10.3109/01480549309031997
Abstract
Captan fungicide (N-(trichloromethylthio)-4-cyclohexene-1,2-dicarboximide) metabolism in two human volunteers rapidly yields THPI (tetrahydrophthalimide) and TTCA (thiazolidine-2-thione-4-carboxylic acid). The work was done to evaluate usefulness of TTCA and THPI as biomarkers of occupational exposure and to compare human and rat dermal absorption and metabolism. THPI in 12h urine ranged from MDL (5 ppb) to 640 ppb and was stable for at least one year. TTCA was also a stable metabolite, but the MDL was 50 ppb. THPI was detectable in urine for 7 2 hours following oral dosages of 1 mg/kg, but most was eliminated 0–24 h. No THPI was detectable in urine following application of a chloroform solution to hands, forearms, or inguinal region. Dermal absorption and metabolism of captan are substantially different in humans and rats.Keywords
This publication has 8 references indexed in Scilit:
- Use of Biological Monitoring Data from Pesticide Users in Making Pesticide Regulatory Decisions in CaliforniaPublished by American Chemical Society (ACS) ,1988
- Captan residues on strawberries and estimates of exposure to pickersBulletin of Environmental Contamination and Toxicology, 1987
- Experimental human exposure to carbon disulfideInternationales Archiv für Arbeitsmedizin, 1987
- Worker reentry into captan-treated grape fields in CaliforniaArchives of Environmental Contamination and Toxicology, 1986
- Worker reentry studies for captan applied to strawberries in CaliforniaJournal of Agricultural and Food Chemistry, 1984
- Simultaneous dermal exposure to captan and benomyl by strawberry harvestersJournal of Agricultural and Food Chemistry, 1983
- Determination of Thio Compounds in Urine of Workers Exposed to Carbon DisulfideArchives of environmental health, 1981
- The Fate ofN-Trichloro[14C]methylthio-4-cyclohexene-1,2-dicarboximide ([14C]Captan) in the RatXenobiotica, 1974