Phenolphthalein stimulates the formation of histamine, 5‐hydroxytryptamine and prostaglandin‐like material by rat jejunum, ileum and colon

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Abstract
1 The effects of Phenolphthalein on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material by rat intestine were examined in vivo. 2 Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT and prostaglandin-like material, and indomethacin reduced these increases. 3 The data support the idea that the laxative effect of Phenolphthalein is due to increased intestinal production of prostaglandin, histamine and 5-HT.