AN ATTEMPT TO STRIKE A BALANCE OF CARBOHYDRATE METABOLISM AT THE TIME OF RAPID CHANGES IN BLOOD SUGAR AND LIVER GLYCOGEN

Abstract
From 2 to 8 hr. following decapitation (cats) glycogenesis exceeds glycogenolysis in the liver. This effect is due, not to the preliminary anesthesia, but to the act of decapitation. The blood sugar can not be the source of all the newly formed glycogen. Later glycogenolysis exceeds glycogenesis, the blood sugar remaining constant. On following the respiratory exchange, it was found impossible to account for the extra loss of carbohydrate through combustion. The loss in hepatic glycogen in decapitate cats after anesthesia, asphyxia, adrenalin injection, and splanchnic stimulation exceeds the coincident increase in free sugar in the blood and liver, the blood being taken as 1/13 the body weight. Adrenalectomy abolished the hyperglycemic effects of asphyxia for a period of less than 4 hr.

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