The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae

1 May 1998

journal article
Published by Oxford University Press (OUP) in FEMS Microbiology Letters

Vol. 162 (1) , 155-160
https://doi.org/10.1016/s0378-1097(98)00118-9

Abstract

We report the finding of a Saccharomyces cerevisiae gene necessary for growth in culture media with d -xylulose as the sole carbon source. This gene corresponds to the YGR194c open reading frame that we have previously described, and it is renamed now XKS1 . Data bank comparisons of the protein encoded by the XKS1 gene showed significant homology with different xylulokinases, indicating a possible role in xylulose phosphorylation. The wild-type gene in a centromeric plasmid complemented defective growth of xks1 S. cerevisiae mutant strains in xylulose. By contrast, overexpression negatively influenced cell growth in this carbon source.

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