An Epidemiological Study of Legg-Perthes Disease

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Abstract
One hundred and eighty-eight typical cases of Legg-Perthes disease were analyzed with respect to possible genetic, constitutional, and environmental etiological factors. In agreement with previous reports, the condition was found to predominate in white boys from three to twelve years old. Female and bilateral cases occurred at younger ages. A definite genetic predisposition was not ascertained. There was a higher than expected familial incidence, but two pairs of monozygotic twins were discordant for Legg-Perthes disease. The study patients had normal parental ages and birth order, but showed a consistent retardation of skeletal maturation. Low birth weight was suggested in female patients and all showed a tendency toward short stature. Infections, trauma, and other congenital anomalies were not found to associate with Legg-Perthes disease.

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