Adhesion of Fibrin Clots to Tissue

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Abstract
Fibrin clots were formed from partly purified bovine Fraction I (3 g. fibrinogen/1.) and thrombin (1 [mu]/cc.) between a stretched tissue surface and a cloth-covered disc. The force necessary to separate the clot from the surface was then measured under saline to eliminate surface tension. Of the 4 tissues employed, artery, vein, peritoneum and muscle, adhesion to artery was the weakest (1 g./cm.2). Adhesion to vein, peritoneum and muscle was stronger (2 g./cm.2). Platelets had a deleterious effect on adhesion to vein, artery and peritoneum with half the normal concn. reducing adhesion to a third or less. On muscle, however, platelets increased adhesion up to 2-fold. Red blood corpuscles had no effect on adhesion. In contrast, whole serum increased adhesion markedly, up to 3-fold on vein and peritoneum (7 g./cm.2). and up to 5-fold on muscle (15 g./ cm.2). This effect was not caused by albumin, globulin or cold-insoluble globulin, but must be ascribed to an unknown, moderately labile factor. Ca and citrate did not influence adhesion in moderate concn. In measurements on human bloods and plasmas most samples showed about twice the adhesion of control fibrinogen solus. (4 g./cm.2) but occasional individuals were very much higher (10-40 g./cm.2).
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