STUDIES IN THE ENHANCEMENT OF TUMOR-IMMUNITY BY COUPLING STRONG ANTIGENS TO TUMOR-CELLS (HETEROGENIZATION OF TUMORS) - HELPER T-CELL CLONES AGAINST PPD HELP OTHER T-CELLS MOUNT ANTI-TUMOR RESPONSES TO PPD-COUPLED TUMOR-CELLS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 51  (4) , 755-763
Abstract
PPD[purified protein derivative]-reactive T cell clones were used to analyze the nature of T lymphocytes that are involved in the heterogenization of tumor cells. This is a phenomenon where coupling tumor cells to a strong antigen (in this case PPD) causes an enhanced immune response to tumor-specific antigens to be elicited providing that the host shows T cell immunity to the strong antigen (in this case is BCG positive). Clones of T cells with the Lyt1+2- phenotype which were unable to mediate delayed-type hypersensitivity but which provided efficient help to hapten-primed B cells potentiated anti-tumor immunity in BCG-negative syngeneic mice when immunized with Con-A[concanavalin A]-PPD coupled, X-irradiated [mouse fibrosarcoma] MC6A tumor cells. There appears to be a mechanism whereby a helper T cell response to 1 antigen can provide help for the generation of a T cell response to a linked antigen which is analogous to the well-known phenomenon of help to hapten primed B cells. The clones of T cells that help B cells the best are those that give maximal augmentation of T cell immunity.

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