HISTOCHEMICAL STUDIES ON THE LOCALIZATION OF ADENOSINE TRIPHOSPHATASE IN THE CEREBELLUM OF THE RAT

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Abstract
A study was made of the detailed histochemical distribution of adenosine triphosphatase among the various constituents of the cerebellum of rat. The white matter is negative, the glomeruli and thin cytoplasmic rims of granule cells show enzymic activity. Beside a moderate staining of the molecular layer, various patterns of distribution have been observed in the nuclei and cytoplasm of Purkinje cells. A correlation between these stages suggests possibility of movement of the enzyme from the central part of the nucleus to the periphery, with further leaching of the enzyme into the perinuclear zone of the cytoplasm. Furthermore, perinuclear, central and peripheral stages suggest that the enzymic activity shifts toward the periphery of the cell. The morphological nature of ATPase positive bodies, distributed in different fashions, has been discussed in relation to the Golgi bodies and the endoplasmic reticulum and Nissl bodies. The physiological role of the enzyme with reference to its movement and the possible mechanism for such movement has also been discussed.