White Matter Lesions and Cognitive Deterioration in Presymptomatic Carriers of the Amyloid Precursor Protein Gene Codon 693 Mutation

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Abstract
Objective: To determine early manifestations of hereditary cerebral hemorrhage with amyloidosis (Dutch). Design: Survey. Setting: Neurologic outpatient department of the University Hospital Leiden in the Netherlands. Participants: Ten presymptomatic carriers of the amyloid precursor protein gene codon 693 mutation. Main Outcome Measurements: Extensive neuropsychological examination and cerebral magnetic resonance imaging. Results: Six subjects older than 40 years showed white matter hyperintensities on magnetic resonance imaging. Three of these six individuals had signs of cognitive deterioration. The four younger subjects (age, Conclusions: We suggest that white matter hyperintensities in hereditary cerebral hemorrhage with amyloidosis (Dutch) are probably caused by chronic ischemia due to stenosis of the meningocortical arterioles, which becomes visible on magnetic resonance imaging scans in individuals who are between the ages of 30 and 40 years. The finding of cognitive deterioration in three of 10 presymptomatic mutation carriers supports the finding that in hereditary cerebral hemorrhage with amyloidosis (Dutch), deterioration can occur without stroke. A direct relation between cognitive deterioration and white matter hyperintensities is unlikely, because only half of the individuals with white matter hyperintensities showed signs of deterioration.