Rules for Peptide Presentation by MHC Class II Molecules
- 1 January 1993
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 10 (4) , 301-311
- https://doi.org/10.3109/08830189309061705
Abstract
Molecules of the major histocompatibility complex (MHC) were first discovered for their importance in the Rejection of tissue grafts between unrelated individuals. If these individuals differ at one or more loci within the MHC, the grafts are Rapidly Rejected. The Rejection process involves Recognition of foreign MHC molecules by T lymphocytes and the Rapid destruction by these cells of the grafted tissue cells. The MHC is a highly polymorphic complex of genes, making tissue grafting between unrelated individuals virtually impossible. Thus, it stimulated a great deal of work when organ transplantation became technically feasible.Keywords
This publication has 22 references indexed in Scilit:
- Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A dScience, 1992
- Proteolysis, proteasomes and antigen presentationNature, 1992
- Peptides tailored to perfection?Current Biology, 1992
- Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass SpectrometryScience, 1992
- Sequence analysis of peptides bound to MHC class II moleculesNature, 1991
- Identification of self peptides bound to purified HLA-B27Nature, 1991
- The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformationNature, 1991
- Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporterNature, 1991
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature, 1991
- Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb moleculeNature, 1990