The Clinical Use of Diuretics

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Abstract
Adjuvant Therapy — Spironolactone and TriamtereneIf the underlying disease progresses, it may eventually become impossible to control the formation of edema on a program that includes tolerable levels of salt restriction and administration of benzothiadiazides. One explanation for the development of the thiazide-fast state is an increase in sodium reabsorption at sites in the nephron both proximal and distal to those where thiazides act, including the sites whose activity is enhanced by aldosterone. Under these circumstances, renewed diuresis will often result from the addition of an agent such as spironolactone or triamterene to the regimen. Substitution of one of . . .

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