The mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 13 (4-6) , 521-530
- https://doi.org/10.1080/15287398409530517
Abstract
Seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 Ames tester strains (TA92, TA94, TA97, TA98, TA100, TA102). The 8 compounds were chemicals isolated from 3 Nigerian medicinal plants: Afraegle paniculata, Clausena anisata and Azadirachta indica. Different preparations of the former were taken by Nigerians for gut disturbances, and a concoction of the latter called Agbo was taken as an antimalarial. Marmesin and imperatorin were mutagenic in all tester strains except TA94 and TA102. The mutagenicity potencies of marmesin and imperatorin were 20 and 0.2, respectively. Mutagenicity was highest in TA98 and TA100 for both compounds. Marmesin was optimally mutagenic at 1.04 .mu.g, and imperatorin at 30.0 .mu.g. Microsomal activation was not required for mutagenicity of both compounds.This publication has 14 references indexed in Scilit:
- Hepatocarcinogens in Nigerian FoodstuffsPublished by S. Karger AG ,1978
- A new carbazole alkaloid and coumarins from roots of Clausena anisataPhytochemistry, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Evidence that caffeine, 8-methoxypsoralen and steroidal diamines are frameshift mutagens for E. coli K-12Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.Proceedings of the National Academy of Sciences, 1975
- Coumarins and other components of Afraegle paniculataPhytochemistry, 1973
- A comparison of chemically induced reversion patterns of salmonella typhimurium and saccharomyces cerevisiae mutants, using in vitro plate testsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- Psoralen monoadducts and interstrand cross-links in DNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
- A Cancer Rate Survey in Ibadan, Western Nigeria, 1960-63British Journal of Cancer, 1965
- Differences in Survival Curve Shapes for Formal Multi-target and Multi-hit ModelsPhysics in Medicine & Biology, 1964