Regional cerebral blood flow in the rat as determined by particle distribution and by diffusible tracer.

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Abstract
Measurements of total and regional cerebral blood flow (CBF) in paralyzed rats maintained on 70% N20/30% O2 obtained by a diffusible tracer technique, iodoantipyrine and by a particle distribution method, microspheres, were compared. Total CBF values were in good agreement, 0.86 .+-. 0.07 ml/g per min (PaCO2 [partial pressure of arterial CO2] 37.3 .+-. 1.5, iodoantipyrine method) and 0.88 .+-. 0.02 (PaCO2 36.2 .+-. 0.8, microsphere method). Regional cerebral blood flows showed good agreement with the 2 methods, with highest flow in the colliculi, striatum and cerebral cortex and lowest flows in the hypothalamus, pons medulla and cerebellum. The iodoantipyrine method is technically easier to perform and had a higher precision.