Reactions of Sodium Borohydride in Acidic Media; XVI.1 N-Methylation of Amines with Paraformaldehyde/Trifluoroacetic Acid
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (08) , 709-711
- https://doi.org/10.1055/s-1987-28053
Abstract
Primary and secondary amines are N-methylated to afford tertiary amines with the combination of paraformaldehyde, sodium borohydride, and trifluoroacetic acid.Keywords
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