Experimental Porphyria. I. Isolation of Uroporphyrin I from Bone Marrow of Lead Poisoned Rabbits.
- 1 March 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 79 (3) , 459-462
- https://doi.org/10.3181/00379727-79-19412
Abstract
Summary and Conclusions 1. Crystalline uroporphyrin I has been isolated from the bone marrow of lead poisoned rabbits and found to be identical with uroporphyrin I isolated from the urine of a patient with photosensitive (erythropoietic) porphyria. 2. The bone marrow of rabbits with acute or chronic lead poisoning has been found to contain from 15 to 844 μg of uroporphyrin I per 100 ml. 3. In experimental lead poisoning, significant amounts of uroporphyrin are found in the circulating red blood cells only during the very acute stage. Erythrocyte coproporphyrin is likewise increased markedly only during the acute phase.Keywords
This publication has 3 references indexed in Scilit:
- Qualitative Analysis of the Porphyrins by Partition ChromatographyScandinavian Journal of Clinical and Laboratory Investigation, 1948
- On Naturally Occurring Porphyrins in the Central Nervous SystemScience, 1944
- A reinvestigation of turacin, the copper porphyrin pigment of certain birds belonging to the musophagidaeProceedings of the Royal Society of London. B. Biological Sciences, 1939