Studies on the West African I Strain of Plasmodium falciparum in Aotus trivirgatus Monkeys

Publisher Website
Google Scholar
Abstract
The West African I strain of P. falciparum was isolated from a pilot who had an overnight stay in Nigeria. Once established in the A. trivirgatus griseimembra monkey, the parasite produced high parasitemias and readily infected mosquitoes. Anopheles freeborni and A. maculatus mosquitoes transmitted the infection to additional animals. Infected salivary glands were also seen in A. culcifacies. Comparative infectivity studies indicated that the most susceptible mosquito was A. freeborni, followed by A. culcifacies, A. maculatus and A. balabacensis balabacensis. Only 2 A. albimanus mosquitoes were infected of 450 examined. The one A. trivirgatus trivirgatus monkey inoculated with this strain had very low levels of parasitemia.