DIAZEPAM: INTRAVENOUS INFUSION IN the TREATMENT of STATUS EPILEPTICUS

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Abstract
As the anticonvulsant plasma level of diazepam (DZP) after i.v. injection is maintained only for a short period, it is profitable to administer DZP as an i.v. infusion. It has been claimed that DZP cannot be mixed with dextrose injection as DZP would precipitate. As this is in contrast to clinical experience, DZP of various brands was added to dextrose injections. A precipitate was found in dextrose injections containing Valium and Stesolid; Diazepam AL was only slightly cloudy. The concentration of DZP was the same in all the samples and corresponded to the calculated concentration. The precipitate in the solutions with Valium and Stesolid which did not pass the filter must be due to additives, most probably benzoates. The infusion mode of administration is recommended as one of the most effective in the acute treatment of status epilepticus.

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