STUDY OF CELLULAR DIVISION CYCLE OF NORMAL AND ABNORMAL SUBJECTS USING BRDU

  • 1 January 1976
    • journal article
    • research article
    • Vol. 19  (2) , 95-102
Abstract
Chromosome modifications induced by BrdU [bromodeoxy uridine] allow a study of the cell division cycle during 3 consecutive generations. Among normal lymphocytes the cell cycle varies in duration, but for the majority of cells, is a little shorter than 20 h. In trisomy 21 individuals the mean cell cycle is shorter, around 16 h. In Fanconi''s anemia, the cell cycle is slowed down and its duration is approximatively twice that of normal individuals. Endoreduplicating cells seem to have the cycle of longest duration.