Variability of the Region of the Herpes Simplex Virus Type 1 Genome Yielding Defective DNA: Smal Fragment Polymorphism
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 23 (3) , 131-139
- https://doi.org/10.1159/000149596
Abstract
A Smal map of class I defective DNA of herpes simplex virus type 1 (HSVl) was constructed using a set of deletion hybrid phages. Four Smal fragments on the defective DNA had a variability in length common among 15 HSVl isolates: the 1.45 kilobase (kb) fragment located within the BamHI-Z (map coordinates 0.936–0.949) fragment, the 0.92-kb fragment neighboring on the ‘a’ sequence, the 0.44-kb fragment containing the intervening sequence of immediate-early mRNA-5 gene, and the 0.205-kb fragment corresponding to the ‘a’ sequence. The four Smal fragments have several sets of reiterated sequences, among which the 1.45- and 0.92-kb fragments hybridized with mammalian cellular DNAs (human, monkey, rabbit, and mouse).Keywords
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