Detection of thiopentone‐reactive IgE antibodies following anaphylactoid reactions during anaesthesia
- 1 September 1986
- journal article
- research article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 16 (5) , 493-498
- https://doi.org/10.1111/j.1365-2222.1986.tb01984.x
Abstract
A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone-reactive IgE antibodies were found in the sera of two patients who had experienced life-threatening anaphylactoid reactivity occurs between the drug-reactive IgE antibodies and four barbiturate analogues pentobarbitone, phenobarbitone, barbitone and methohexital. The assay should supplement skin testing for the detection of patients with potentially lethal sensitivity to thiopentone.This publication has 15 references indexed in Scilit:
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