Modulation by Insulin and Glucagon of the Rate of [3H] H2O Incorporation into Glycerolipids by Isolated Rat Hepatocytes

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Abstract
Isolated rat hepatocytes in suspension were used to study the effects of insulin and glucagon on [3H]H2O incorporation into glycerolipids. Insulin was found to stimulate the incorporation of 3H into the acyl groups of triacylglycerols, phosphatidylcholines and phosphatidylethanolamines. The incorporation of 3H from [3H]H2O into the glycerol backbone of triacylglycerols is also enhanced by insulin. Glucagon has an inhibitory effect on all these parameters.