Biotin. Its place in evolution
- 1 June 1978
- journal article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 11 (2) , 171-187
- https://doi.org/10.1007/bf01733892
Abstract
In the previous article we try to give an explanation for the success of models for enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.Keywords
This publication has 88 references indexed in Scilit:
- Structural characterization of thermal prebiotic polypeptidesJournal of Molecular Evolution, 1976
- Coenzymes as fossils of an earlier metabolic stateJournal of Molecular Evolution, 1976
- 1,3 Acyl Migrations in Unsaturated Triad (Allyloid) Systems. Rearrangements of N-(2,4-Dinitrophenyl)benzimidoyl BenzoatesJournal of the American Chemical Society, 1967
- Studies of the Mechanism of Biotin CatalysisJournal of the American Chemical Society, 1965
- Carbodiimides. VIII.1 Observations on the Reactions of Carbodiimides with Acids and Some New Applications in the Synthesis of Phosphoric Acid EstersJournal of the American Chemical Society, 1958
- Nitrogen Analogs of Ketenes. IV.1 Reactions with Carboxylic AcidsJournal of the American Chemical Society, 1958
- Crystal Structure of BiotinNature, 1956
- Production of Some Organic Compounds under Possible Primitive Earth Conditions1Journal of the American Chemical Society, 1955
- Synthesis of BiocytinJournal of the American Chemical Society, 1952
- Biotin. IV. Synthesis of 4-Benzamido-3-ketotetrahydrothiopheneJournal of the American Chemical Society, 1944