Absorption and Urinary Excretion of Chloramphenicol and 2 Analogues, Thiocymetin and U-15,442 in Normal Men.

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Abstract
Levels of active drug in serum and urinary excretion were determined in 6 normal adults after single oral doses of 500 mg of chloramphenicol and its 4-methylsulphonylphenyl (dextrosulphenidol, Thiocymetin) and 4-methylmercaptophenyl analogues. Chloramphenicol was the most active in vitro against recently isolated strains of Staphylococcus aureus. Serum levels were quite similar for each of the 3 drugs but tht urinary recovery of Thiocymetin was greater, and sufficiently so to more than offset its inferior antibacterial activity; the same was not true of the other analogue.