Efficacy of different dosing schedules of tobramycin for treating a murine Klebsiella pneumoniae bronchopneumonia
- 1 April 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 19 (4) , 487-491
- https://doi.org/10.1093/jac/19.4.487
Abstract
The efficacy of different dosing schedules of tobramycin for treating a murine Klebsiella bronchopneumonia was compared. Therapeutic efficacy depended upon dosing intervals. In mice treated for four days with a daily dose of 48 mg/kg, dosing intervals of 4 and 8 h allowed cure of 10/10 animals, whereas dosing intervals of 12 and 24h yielded survival rates of only 6/10 (PPin vitro, a post-antibiotic effect of tobramycin against K. pneumoniae was unlikely in vivo since residual concentrations of tobramycin were found in the lung tissue 12 h after dosing, when efficacy starts to decrease. Efficacy also depended to some extent upon the duration of therapy.Keywords
This publication has 1 reference indexed in Scilit:
- Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro modelAntimicrobial Agents and Chemotherapy, 1985