Hemodilution as a Result of Estrogen Therapy. Estrogenic Effects in the Human Female

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Abstract
Sixteen women with minor menstrual irregularities were given 2-4 doses of estrone (5 mg. each) or estradiol dipropionate 0.4 mg. In each instance there was a lowering of the red cell count, hematocrit and hemoglobin during estrogen therapy. Coincidently there was a 15%-21% increase in blood volume. The increase in plasma volume was sufficient to account for the decrease in hematocrit and red cell count. Within 5-8 days following cessation of treatment the blood compositions returned to their pretreatment values. These findings suggest the possibility that estrogen may be a factor in the hemodilution that occurs during pregnancy and that blood volume changes may be correlated with the vasomotor symptoms of the menopause.

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