A Novel Proline-Catalyzed Three-Component Reaction of Ketones, Aldehydes, and Meldrum's Acid

29 October 2001

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 2001 (11) , 1687-1689
https://doi.org/10.1055/s-2001-18095

Abstract

We describe a novel proline-catalyzed three-component domino reaction between ketones, aldehydes and Meldrum's acid. Two new carbon-carbon σ-bonds from three different components are formed in this efficient transformation.

Keywords

MULTICOMPONENT REACTIONS
ORGANOCATALYSIS
C-C COUPLING
COMBINATORIAL CHEMISTRY
DOMINO REACTIONS

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