The effects of various agents in vitro on homocarnosine-carnosine synthetase from rat brain
- 1 July 1976
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (7) , 839-841
- https://doi.org/10.1007/bf02003717
Abstract
The present paper reports the first evidence that homocarnosine-carnosine synthetase from rat brain requires free sulfhydryl groups for activity. The activity of the synthetase can be stabilized by dithioerythritol and inhibited strongly by Cu2+, Cd2+, Hg2+, Zn2+, and to a lesser extent by Ca2+, Ni2+, Li, chlorpromazine, α-methyl DOPA and norepinephrine at the concentrations tested.Keywords
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