Abstract
Tissue aldehydes exhibit a characteristic distribution pattern in the rat kidney. A change of the tissue aldehydes in the intercortico-medullary zone (ICM zone) of the rat kidney concomitant with the estrous cycle has been described. During estrus the aldehydes tend to increase, and during diestrus they decrease. A scheme is presented showing the ideal conditions of the phenomenon. Ovarial hormones alone influence the state of the aldehydes in the ICM zone. Progesterone might not be the hormone responsible for the disappearance of the aldehydes in the ICM zone. The chemical and physiological significance of the phenomenon is discussed.

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