MECHANISMS INVOLVED IN THE RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO PARA -AMINOSALICYLIC ACID,

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Abstract
Reversal of para-aminosalicylic acid-inhibition in susceptible strains of M. tuberculosis was effected by methionine, biotin and tween 80 or by methionine and hypoxanthine. Inhibition of growth of resistant strains of tubercle bacilli by high concentrations of para-aminosalicylic acid was reversed by methionine alone. Resistant strains of M. tuberculosis which had been isolated from patients exhibited either a partial or an absolute growth requirement for oleic acid. Increased resistance to para-aminosalicylic acid was accompanied by a proportionate increase in the competitive ratio of para-aminosalicylic acid to para-aminobenzoic acid.