ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN HYPERTENSIVE PROTEINURIC PREGNANT PATIENTS BY LIGNOCAINE, ALFENTANIL AND MAGNESIUM SULPHATE
Open Access
- 1 February 1991
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 66 (2) , 216-223
- https://doi.org/10.1093/bja/66.2.216
Abstract
The pressor response to intubation is known to be exaggerated in patients with gestational proteinuric hypertension (GPH). The effect of pretreatment with lignocaine 1.5 mg kg−1, magnesium sulphate 40 mg kg−1 or alfentanil 10 μg kg−1 on this pressor response was studied in 69 patients with moderate to severe GPH. Systolic arterial pressure exceeded baseline values for the first 5 min after tracheal intubation in the lignocaine group, with a peak increase of 31.6 (SEM 3.6) mm Hg at 2 min after intubation, but no mean increase in pressure occurred in the two other groups. Following intubation, six of 24 mothers in the alfentanil group, six of 21 in the lignocaine group and one of 24 in the magnesium group (P < 0.05) exhibited a systolic arterial pressure (SAP) greater than 180 mm Hg sustained for 2 min or more. Alfentanil caused the least change in heart rate, but resulted in significant fetal depression.Keywords
This publication has 0 references indexed in Scilit: