Evaluation of the endocrine functions in dystrophia myotonica

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Abstract
Investigation of several endocrine functions was performed in 7 patients with dystrophia myotonica (DM). All patients had hyperinsulinemia. The 4 female patients had normal pituitary-gonadal function; all 3 male patients presented evidence of a primary gonadal failure. Thyroid function was normal in all patients. Four patients displayed abnormal diurnal variations of cortisol secretion. Basal prolactin levels were elevated in 3 patients, 1 of whom also had consistently elevated levels of growth hormone. The investigation adds some new evidence of neuroendocrine dysfunction at the hypothalamic level in DM.