EFFECT OF DELAY IN ADMINISTRATION OF 13-CIS-RETINOIC ACID ON THE INHIBITION OF URINARY-BLADDER CARCINOGENESIS IN THE RAT
- 1 January 1979
- journal article
- research article
- Vol. 39 (8) , 3141-3144
Abstract
The effect of a delay in starting 13-cis-retinoic acid treatment on the inhibition of urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine was studied in male Fischer 344 rats. Animals received a total p.o. [per os] dose of 1200, 1800 or 2400 mg N-butyl-N-(4-hydroxybutyl)nitrosamine over a period of 6 wk. At 1, 5 and 9 wk after the last N-butyl-N-(4-hydroxybutyl)nitrosamine intubation, animals were started on a diet supplemented with 13-cis-retinoic acid (240 mg/kg of laboratory chow) or after the 1st carcinogen intubation for histological evaluation of the bladder. Feeding of 13-cis-retinoic acid reduced the incidence, average number and severity of transitional cell carcinomas and hyperplasia and cellular atypia. Even a 9 wk delay in starting the retinoid feeding did not diminish the ability of 13-cis-retinoic acid to inhibit bladder carcinogenesis.This publication has 5 references indexed in Scilit:
- A Quantitative Dosing Schedule for the Induction of Transitional Cell Carcinomas in Female F344 Rats With the Use of N-Butyl-N-(4-hydroxybutyl)nitrosamine2JNCI Journal of the National Cancer Institute, 1979
- INHIBITORY EFFECT OF 13-CIS-RETINOIC ACID ON URINARY-BLADDER CARCINOGENESIS INDUCED IN C57BL-6 MICE BY N-BUTYL-N-(4-HYDROXYBUTYL)-NITROSAMINE1978
- 13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by N -Butyl- N -(4-hydroxybutyl)nitrosamineScience, 1977
- 13- cis -Retinoic Acid: Inhibition of Bladder Carcinogenesis in the RatScience, 1977
- Stages of transformation in the development of N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced transitional cell carcinomas in the urinary bladder of ratsZeitschrift für Krebsforschung und Klinische Onkologie, 1976