Critical Role for Casein Kinase 2 and Phosphoinositide-3-Kinase in the Interferon-γ–Induced Expression of Monocyte Chemoattractant Protein-1 and Other Key Genes Implicated in Atherosclerosis
- 1 April 2007
- journal article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 27 (4) , 806-812
- https://doi.org/10.1161/01.atv.0000258867.79411.96
Abstract
Objective— The interferon-γ (IFN-γ)–mediated regulation of macrophage gene expression is of crucial importance in the pathogenesis of atherosclerosis. The mechanisms underlying the actions of IFN-γ signaling in macrophages were investigated using monocyte chemoattractant protein (MCP)-1 as a model gene.Keywords
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