Hyperimmunoglobulinemia E syndrome: association with osteoporosis and recurrent fractures.

Abstract
Hyperimmunoglobulinemia E (Job or Buckley) syndrome is an immunodeficiency disease [in humans] associated with recurrent pyogenic infections, chronic eczematoid dermatitis and mucocutaneous candidiasis. Association of this condition with osteoporosis and recurrent fractures is presented by a case report, and by review of other reports describing similar findings. Other immunodeficiency syndromes with associated skeletal abnormalities are discussed. [Radiographic findings are reported.].

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