Cloning and sequence analysis of a human type A/B hnRNP protein
- 17 December 2001
- journal article
- Published by Wiley
- Vol. 290 (1-2) , 159-161
- https://doi.org/10.1016/0014-5793(91)81249-8
Abstract
A cDNA encoding a 284 residue long type A/B hnRNP protein has been cloned. This protein, previously referred to as type C[(1987) J. Biol. Chem. 262, 17126–17137], is an RNA unwinding protein from HeLa 40S hnRNP with a high affinity for G- followed by U-rich sequences. The N-terminal part of the protein contains two consensus RNA binding domains present in a number of other RNA binding proteins. The C-terminal part is glycine-rich and contains a potential ATP/GTP binding loop. The distribution of charged amino acids is highly uneven and there are multiple potential phosphorylation sites.Keywords
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