A β-lactamase belonging to group 2e from oral clinical isolates of Prevotella intermedia
- 15 January 1998
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 158 (2) , 191-194
- https://doi.org/10.1016/s0378-1097(97)00521-1
Abstract
A β-lactamase in oral clinical isolates of Prevotella intermedia that hydrolyzed cefuroxime and cephalothin with rates of 600 and 53.3 respectively, relative to that for cephaloridine (100), was characterized as a 2e-cephalosporinase. Inhibition was observed by clavulanic acid (IC50 0.72 μM), tazobactam (IC50 0.21 μM) and sulbactam (IC50 0.07 μM) and was not inhibited by cloxacillin, EDTA, NaCl or p-CMB. The pI and pH optima were 4.7 and 5.4, respectively.Keywords
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