UPPER AND LOWER AIRWAY HYPER-REACTIVITY IN RECURRENT CROUP

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Abstract
Children (17) with recurrent croup, who had their last episode within 12 mo., were evaluated clinically by allergy skin tests, pulmonary function tests and histamine inhalation challenge. Fourteen showed airway hyperreactivity. Flow-volume loops were obtained after a positive histamine response and compared to post histamine tracings of children with asthma and healthy control subjects. Children with recurrent croup and those with asthma showed a significantly greater fall in maximal expiratory flow rates than that shown in healthy control subjects. Those with recurrent croup had a significantly greater fall in maximal inspiratory flow rates compared to those with asthma and to control subjects. A specific type of airway hyperreactivity suggestive of involvement of upper and lower respiratory tract was seen in children with recurrent croup.

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