Acetylation of P‐Aminohippuric Acid in the Kidney. Renal Clearance of P‐Aminohippuric Acid in the Kidney. Renal Clearance of P‐Aminohippuric Acid and N4‐Acetylated P‐Aminohippuric Acid in Pigs

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Abstract
20 pigs weighing 21–124 kg were used to determine the clearance of PAH, N4‐acetylated PAH and PAHtotal, and for determination of acetylation of PAH and de‐acetylation of N4‐acetylated PAH in the kidney. By examining blood samples taken from a. renalis and v. renalis and urine collected simultaneously, the acetylation and de‐acetylation of PAH and N4‐acetylated PAH in the kidney were determined on 9 pigs. 6 of these acetylated PAH (1.5–10 per cent), while 3 de‐acetylated N4‐acetylated PAH (2–21 per cent). The extraction percentage for PAH and N4‐acetylated PAH were 91 ± 1.4 (S.E.M.) and 84 ± 2.1 respectively. The ratio between clearance of N4‐acetylated PAH and PAH was found to be 1.08 ± 0.07 and between clearance for PAHtotal and PAH 1.01 ± 0.02.

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