Spatial chemical conservation of hot spot interactions in protein-protein complexes
Open Access
- 9 October 2007
- journal article
- Published by Springer Nature in BMC Biology
- Vol. 5 (1) , 43
- https://doi.org/10.1186/1741-7007-5-43
Abstract
Conservation of the spatial binding organizations at the level of physico-chemical interactions is important for the formation and stability of protein-protein complexes as well as protein and drug design. Due to the lack of computational tools for recognition of spatial patterns of interactions shared by a set of protein-protein complexes, the conservation of such interactions has not been addressed previously.Keywords
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