Formation of dTDP-Rhamnose Is Essential for Growth of Mycobacteria
Open Access
- 15 June 2002
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 184 (12) , 3392-3395
- https://doi.org/10.1128/jb.184.12.3392-3395.2002
Abstract
It was determined that the dTDP-rhamnose synthesis gene, rmlD , could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.Keywords
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