FAILURE OF A SUBUNIT BOVINE HERPESVIRUS-1 VACCINE TO PROTECT AGAINST EXPERIMENTAL RESPIRATORY-DISEASE IN CALVES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 45  (1) , 87-91
Abstract
In 2 experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups was previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. Results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field.